This article is a great general overview. The authors begin by discussing the basic diagnosis and assessment of neuropathic pain. Theories of the underlying pathophysiology are discussed as well. Then the authors transition into a discussion of treatment options. A brief overview of Lidoderm Patch, Gabapentin, Opioids, Tramadol and Tricyclic Antidepressants is provided. The articles fails to discuss SSNRIs and Lyrica; however, these medications have similar mechanisms of action to those presented. This article is a good resource for an overview of neuropathic pain for both etiology, diagnostic criteria and management.See its abstract posted below.
Arch Neurol, Nov 2003; 60: 1524 - 1534 http://www.archneurol.com/
Advances in Neuropathic Pain
Diagnosis, Mechanisms, and Treatment Recommendations
Arch Neurol. 2003;60:1524-1534.
Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism–based approach.
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ReplyDeleteInnovative post, very knowledgeable post. Good job. neuropathic pain
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